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Presentation

My research focus on the understanding of the biochemistry of the smell and taste perception.

 

Education

PhD in molecular enzymology at Lorraine University under the supervision of Pr. Guy Branlant. Postodoctoral position in Karolinska Institut in two laboratories: the Brigitta and Staffan Normark laboratory, and the Adnane Achour laboratory.

 

Professional experience

From 2009, Ass. Professor in the Medical/Pharmaceutical school of the Burgundy University.

 

Research topic

I develop three axes focusing on the understanding of the perception of smell and taste at the molecular level. Axe 1: Caracterisation of the human proteins involved in the taste and smell modulation. Axe 2: Decephering the actif site modifications of the Drosophila Glutathione transferase enzymes during their evolution in link with their role in the taste and smell perception. Axe 3: Development of new microbiological organism for the recombinant protein production.

 

Skills

Enzymology, Recombinant protein production and purification, X-ray crystallography, Microbiology, Molecular biology, Biophysical analysis (Circular dichroïsm, Light scattering, Microcalorimetry, Fluorescence spectroscopy).

 

Recent publications

Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure. Data Brief. 2018. Fraichard S., Gonzalez D., Grassein P., Delarue P., Senet P., Nicolaï A., Chavanne E., Mucher E., Artur Y., Ferveur J.F., Heydel J.M., Briand L., Neiers F. (IF : 0.3).

The Crystal Structure of Gurmarin, a Sweet Taste-Suppressing Protein: Identification of the Amino Acid Residues Essential for Inhibition. Chem Senses. 2018. Sigoillot M., Brockhoff A., Neiers F., Poirier N., Belloir C., Legrand P., Charron C., Roblin P., Meyerhof W., Briand L. (IF : 3.2).

Saliva and flavour perception: perspectives. J Agric Food Chem. 2018. Canon F., Neiers F., Guichard E. (IF : 2.9).

Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification. Insect Biochem Mol Biol. 2018 Gonzalez D., Fraichard S., Grassein P., Delarue P., Senet P., Nicolaï A., Chavanne E., Mucher E., Artur Y., Ferveur J.F., Heydel J.M., Briand L., Neiers F.

Effect of high pressure on the antimicrobial activity and secondary structure of the bacteriocin nisin. Innovative Food Science & Emerging Technologies. 2018. Modugnoa C., Loupiac C., Bernarda A., Jossiera A., Neiers F., Perrier-Cornet J.M., Simonin H. (IF : 1.2).

Biophysical and functional characterization of the N-terminal domain of the cat T1R1 umami taste receptor expressed in Escherichia coli. PLoS One. 2017. Belloir C., Savistchenko J., Neiers F., Taylor A.J., McGrane S., Briand L. (IF : 2.8).

A self-inducible heterologous protein expression system in Escherichia coli. Sci Rep. 2016 Briand L., Marcion G., Kriznik A., Heydel J.M., Artur Y., Garrido C., Seigneuric R., Neiers F.

What Does Diabetes "Taste" Like? Curr Diab Rep. 2016 Neiers F, Canivenc-Lavier M.C., Briand L.

Binding of Divalent Cations to Polygalacturonate: A Mechanism Driven by the Hydration Water. J Phys Chem B. 2016 (IF : 3.2) Huynh U.T., Lerbret A., Neiers F., Chambin O., Assifaoui A.

Sweeteners and sweetness enhancers. Curr Opin Clin Nutr Metab Care. Belloir C., Neiers F., Briand L.

N-terminal amino acids are essential for human heat shock protein 70 dimerization. Cell Stress Chaperones. 2015 Marcion G., Seigneuric R., Chavanne E., Artur Y., Briand L., Hadi T., Gobbo J., Garrido C., Neiers F. (IF : 2.7).

Functional roles of the sweet taste receptor in oral and extraoral tissues. Curr Opin Clin Nutr Metab Care. 2014 Apr 23. Laffitte A., Neiers F., Briand L. (IF : 4.5).

Structural behaviour differences in low methoxy pectin solutions in the presence of divalent cations (Ca(2+) and Zn(2+)): a process driven by the binding mechanism of the cation with the galacturonate unit. Soft Matter. 2014. Assifaoui A., Lerbret A., Uyen H.T., Neiers F., Chambin O., Loupiac C., Cousin F. (IF : 4.2).

 

PhD surpervision

Anni Laffitte, PhD in 2017.

Christine Belloir and Elodie Gonis both in thesis.

 

Additional responsibilities

Teaching in medical and pharmaceutical school: biochemistry, enzymology, structural biology.